Clark level of invasion

A method for determining the prognosis (outlook) with melanoma. The method was devised by the pathologist Wallace Clark and measures the depth of penetration of a melanoma into the skin according to anatomic layer. There are five Clark levels of invasion: {{}}Level I: Melanomas confined to the outermost layer of the skin, the epidermis. Also called "melanoma in-situ." Level II: Penetration by melanomas into the second layer of the skin, the dermis. Levels III-IV: Melanomas invade deeper through the dermis, but are still contained completely within the skin. Level V: Penetration of melanoma into the fat of the skin beneath the dermis, penetration into the third layer of the skin, the subcutis. The Clark levels provide a system to relate the degree of penetration of melanoma into the skin to the 5-year survival rate after surgical removal of the melanoma. Another melanoma measurement system, that of Breslow thickness, named after its originator Alexander Breslow, is in wider use today. In it, invasive tumor thickness is used to predict 5-year survival. For example, a thickness of the melanoma of less than 0.76 millimeters is associated with a 5-year survival of 97% of patients whereas a tumor thickness of more than 8.0 millimeters is associated with 5-year survival of 32%.

Medical dictionary. 2011.

Look at other dictionaries:

  • Clark-Level — Der Clark Level ist ein histologisches System, um die Stadien eines malignen Melanoms einzuteilen. Dabei wird in operativ entfernten Krebsgewebe und den noch umgebenden gesunden Hautanteilen bei einer mikroskopischen Untersuchung bestimmt, wie… …   Deutsch Wikipedia

  • Clark Level — Der Clark Level ist ein histologisches System, um die Stadien eines malignen Melanoms einzuteilen. Dabei wird in operativ entfernten Krebsgewebe und den noch umgebenden gesunden Hautanteilen bei einer mikroskopischen Untersuchung bestimmt, wie… …   Deutsch Wikipedia

  • level — 1. Any rank, position, or status in a graded scale of values. 2. A test for determining such rank or position. acoustic reference l. the biological reference l. for sound measurements. When the term decibel is used to …   Medical dictionary

  • Breslow-Level — Die Tumordicke nach Breslow (oder auch Breslow Level) ist eine histologische Klassifikation, um die Stadien eines malignen Melanoms und die daraus abgeleitete Prognose zu beurteilen. Dabei wird in operativ entferntem Krebsgewebe die absolute… …   Deutsch Wikipedia

  • United States invasion of Panama — Invasion of Panama US soldiers prepare to take La Comandancia in the El Chorrillo neighborhood of Panama City, December 1989 …   Wikipedia

  • Cecil Lee Clark — Lieutenant Colonel Cecil Lee Clark (born 1961) is a native of Gilliam, Louisiana but grew up just outside Blanchard, Louisiana. He is notable for his contributions in the publishing of the U.S. Army Marine Corps new Counterinsurgency Field Manual …   Wikipedia

  • Breslow thickness — A method for determining the prognosis with melanoma. The thickness of a melanoma is related to the 5 year survival rate after surgical removal of the tumor. Named for the physician Alexander Breslow who in 1975 observed that as the thickness of… …   Medical dictionary

  • Melanoma thickness — A method for determining the prognosis (outlook) with melanoma. The thickness of a melanoma is related to the 5 year survival rate after surgical removal of the tumor. Also called Breslow thickness. Named for the physician Alexander Breslow who… …   Medical dictionary

  • Melanoma — Classification and external resources A melanoma ICD 10 C43 …   Wikipedia

  • Tumordicke nach Breslow — Die Tumordicke nach Breslow (oder auch Breslow Level) ist eine histologische Klassifikation, um die Stadien eines malignen Melanoms und die daraus abgeleitete Prognose zu beurteilen. Dabei wird in operativ entferntem Krebsgewebe die absolute… …   Deutsch Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.