systemic scleroderma

a systemic disorder of the connective tissue characterized by fibrosis with hardening and thickening of the skin, as well as abnormalities of both microvasculature (telangiectasias) and larger vessels (Raynaud phenomenon); there are also fibrotic degenerative changes in body organs such as the heart, lungs, kidneys, and gastrointestinal tract. It may be confined to the face and hands for long periods or may progress, spread diffusely, and become generalized. Called also diffuse s. and systemic sclerosis. See also CREST syndrome.

Systemic scleroderma with characteristic tense shiny skin and fixed clawlike position of the fingers caused by acro-osteolysis and flexion contractures.


Medical dictionary. 2011.

Look at other dictionaries:

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  • systemic sclerosis — a rare connective tissue disease affecting many systems in the body, mainly in women (3–6:1) in their forties. Genetic and autoimmune factors may be implicated. Besides scleroderma, there may be involvement of the lungs, with pulmonary fibrosis;… …   The new mediacal dictionary

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