peptidyl-dipeptidase A

pep·ti·dyl-di·pep·ti·dase A (pepґtĭ-dəl di-pepґtĭ-dās) [EC 3.4.15.1] an enzyme of the hydrolase class that catalyzes the cleavage of a dipeptide from the C-terminal end of an oligopeptide; it is a zinc protein found on the luminal surface of vascular endothelial cells in the lungs and other tissues. When catalyzing the cleavage of angiotensin I to form the activated angiotensin II, it is also called angiotensin-converting enzyme; when catalyzing the cleavage and inactivation of kinins, it is also called kininase II. Called also dipeptidyl carboxypeptidase I.

Medical dictionary. 2011.

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  • peptidyl dipeptidase A — A zinc containing hydrolase cleaving C terminal dipeptides from a variety of substrates, including angiotensin I, which is converted to angiotensin II and histidylleucine (an important step in the metabolism of certain vasopressor agents). Drugs… …   Medical dictionary

  • peptidyl-dipeptidase — pep·ti·dyl di·pep·ti·dase (pep″tĭ dəl″ di pepґtĭ dās) [EC 3.4.15] any member of a sub subclass of enzymes of the hydrolase class that catalyze the cleavage of a dipeptide residue from a free C terminal end of a… …   Medical dictionary

  • kininase II — peptidyl dipeptidase A …   Medical dictionary

  • List of EC numbers (EC 3) — This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 3.1: Acting on Ester BondsEC… …   Wikipedia

  • Hydrolase — Cristal de lysozyme Les hydrolases constituent une classe d enzymes qui catalysent les réactions d hydrolyse de molécules suivant la réaction générale : R R + H2O ⇌ R OH + R H On y trouve par exemple les estérases, qui hydrolysent les …   Wikipédia en Français

  • EC 3.4 — Le groupe EC3.4 est un groupe d enzymes appartenant à la famille des hydrolases. Leur rôle est de découper un polypeptide, d où leur nom générique de peptidases. La réaction chimique qu elles catalysent est : AA1 CO NH AA2 + H2O ⇌ AA1 COOH + …   Wikipédia en Français

  • peptidase — Any enzyme capable of hydrolyzing a peptide bond of a peptide; e.g., carboxypeptidases, aminopeptidases. SYN: peptide hydrolase. p. D SYN: proline dipeptidase. p. P SYN: peptidyl dipeptidase A. * * * pep·ti·dase pep tə .dās, .dāz n an enzyme that …   Medical dictionary

  • Angiotensin-converting enzyme — Angiotensin I converting enzyme (ACE, EC number|3.4.15.1) is an exopeptidase.FunctionsIt has two primary functions: * it catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. [GeorgiaPhysiology|7/7ch09/7ch09p16] * …   Wikipedia

  • Bradykinin — Masse/Länge …   Deutsch Wikipedia

  • Enzyme De Conversion De L'angiotensine — Pour les articles homonymes, voir conversion. L enzyme de conversion de l angiotensine ou plus simplement enzyme de conversion (ECA, EC 3.4.15.1) est une exopeptidase qui catalyse la conversion de l …   Wikipédia en Français

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