L-lactate dehydrogenase

L-lac·tate de·hy·dro·gen·ase (LDH) (lakґtāt de-hiґdro-jən-ās) [EC] an enzyme of the oxidoreductase class that catalyzes the reduction of pyruvate to (S)-lactate, using NADH as an electron donor. The reaction is the final step in glycolysis (white fibers). The reverse reaction is the first step in the combustion of lactate (heart, red fibers) or its conversion to glucose (liver). The enzyme occurs in the cytoplasm of nearly all cells. It is a tetramer containing M (muscle) and H (heart) subunits; it exists as five distinct isozymes (M4, M3H, M2H2, MH3, H4). Identification of isozyme types in serum is used for clinical diagnosis.

Medical dictionary. 2011.

Look at other dictionaries:

  • Lactate dehydrogenase — Identifiers EC number CAS number 9001 60 9 …   Wikipedia

  • Lactate dehydrogenase elevating virus — (LDV) is a virus that swiftly multiplies without potentially harming the host. LDV does slightly harm the immune system, causing it to be less efficient. Tests on mice show that LDV is more commonly found in the liver, spleen, lymph nodes, and… …   Wikipedia

  • lactate dehydrogenase — lactate dehydrogenase. См. лактатдегидрогеназа. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Lactate dehydrogenase — An enzyme that catalyzes the conversion of lactate to pyruvate. This is an important step in energy production in cells. Many different types of cells in the body contain this enzyme. Some of the organs relatively rich in lactate dehydrogenase… …   Medical dictionary

  • lactate dehydrogenase — noun : any of a group of isoenzymes that catalyze reversibly the conversion of pyruvic acid to lactic acid, are found especially in the liver, kidneys, striated muscle, and the myocardium, and tend to accumulate in the body when these organs or… …   Useful english dictionary

  • lactate dehydrogenase — LDH. One of a group of enzymes found in the blood and other body tissues and involved in energy production in cells. An increased amount of lactate dehydrogenase in the blood may be a sign of tissue damage and some types of cancer or other… …   English dictionary of cancer terms

  • lactate dehydrogenase — The enzyme that catalyses the formation and removal of lactate according to the equation: pyruvate + NADH = lactate + NAD. The appearance of LDH in the medium is often used as an indication of cell death and the release of cytoplasmic… …   Dictionary of molecular biology

  • lactate dehydrogenase — Biochem. an enzyme that catalyzes the interconversion of pyruvate and lactate, an important step in carbohydrate metabolism: elevated serum levels indicate injury to kidney, skeletal muscle, or heart muscle. Abbr.: LDH * * * …   Universalium

  • lactate dehydrogenase — lac′tate dehy′drogenase n. biochem. an enzyme of carbohydrate metabolism that interchanges lactate and pyruvate: elevated blood levels indicate injury to kidney, heart, or muscles Abbr.: LDH …   From formal English to slang

  • lactate dehydrogenase — /ˌlækteɪt dihaɪˈdrɒdʒəneɪz/ (say .laktayt deehuy drojuhnayz) noun an enzyme existing in multiple forms which catalyses the oxidation of lactate to pyruvic acid used in diagnosis of myocardial infarction …   Australian English dictionary

  • lactate dehydrogenase — noun Date: 1966 any of a group of isoenzymes that catalyze reversibly the conversion of pyruvic acid to lactic acid called also lactic dehydrogenase …   New Collegiate Dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.