HMG-CoA reductase inhibitors

a group of drugs that competitively inhibit the enzyme hydroxymethylglutaryl-CoA reductase, which catalyzes the rate-limiting step in cholesterol biosynthesis; used to lower plasma lipoprotein levels in treatment of hyperlipoproteinemia. Called also statins.

Medical dictionary. 2011.

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  • HMG-CoA reductase — protein Name = 3 hydroxy 3 methylglutaryl Coenzyme A reductase caption = HMG CoA reductase width = 200 HGNCid = 5006 Symbol = HMGCR AltSymbols = EntrezGene = 3156 OMIM = 142910 RefSeq = NM 000859 UniProt = P04035 PDB = ECnumber = 1.1.1.88… …   Wikipedia

  • Inhibiteur de la HMG-CoA réductase — Statine Les statines (ou inhibiteurs de la HMG CoA réductase) forment une classe d hypolipidémiants, utilisés comme médicaments pour baisser la cholestérolémie de personnes qui risquent une maladie cardiovasculaire à cause de leur… …   Wikipédia en Français

  • Inhibiteur de l'HMG co-réductase — Statine Les statines (ou inhibiteurs de la HMG CoA réductase) forment une classe d hypolipidémiants, utilisés comme médicaments pour baisser la cholestérolémie de personnes qui risquent une maladie cardiovasculaire à cause de leur… …   Wikipédia en Français

  • 7-Dehydrocholesterol reductase — Identifiers Symbols DHCR7; SLOS External IDs OMIM …   Wikipedia

  • Dihydrofolate reductase inhibitor — A dihydrofolate reductase inhibitor is a molecule that inhibits the function of dihydrofolate reductase, and is a type of antifolate. Since folate is needed by rapidly dividing cells to make thymine, this effect may be used to therapeutic… …   Wikipedia

  • Statin — This article is about the group of cholesterol lowering drugs. For the amino acid, see Statine. Lovastatin, a compound isolated from Aspergillus terreus, was the first statin to be marketed. Statins (or HMG CoA reductase inhibitors) are a class… …   Wikipedia

  • Statin development — The discovery of HMG CoA (3 hydroxy 3 methylglutaryl CoA) reductase inhibitors, called statins, was a breakthrough in the prevention of hypercholesterolemia and related diseases. Hypercholesterolemia is considered to be one of the major risk… …   Wikipedia

  • Estatina — Saltar a navegación, búsqueda Est …   Wikipedia Español

  • inhibitor — 1. An agent that restrains or retards physiologic, chemical, or enzymatic action. 2. A nerve, stimulation of which represses activity. SEE ALSO: inhibition. α glucosidase i. an oral agent that aids in th …   Medical dictionary

  • Mevalonate inhibition — is used to define the effects of medicines based on HMG CoA reductase enzyme inhibitors to control the products of the mevalonate pathway. This term addresses the effects of long term restriction of mevalonate production in cell membranes by the… …   Wikipedia

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