- Carcinoembryonic antigen
- Carcinoembryonic antigen (CEA) is a protein found in many types of cells but associated with tumors and the developing fetus. CEA is tested in blood. The normal range is Benign conditions that can increase CEA include smoking, infection, inflammatory bowel disease, pancreatitis, cirrhosis of the liver, and some benign tumors (in the same organs which have cancers with increased CEA). Benign disease does not usually cause a CEA increase over 10 ng/ml. The main use of CEA is as a tumor marker, especially with intestinal cancer. The most common cancers that elevate CEA are in the colon and rectum. Others: cancer of the pancreas, stomach, breast, lung, and certain types of thyroid and ovarian cancer.
Levels over 20 ng/ml before therapy are associated with cancer which has already metastasized (spread). CEA is useful in monitoring the treatment of CEA-rich tumors. If the CEA is high before treatment, it should fall to normal after successful therapy. A rising CEA level indicates progression or recurrence of the cancer. (Chemotherapy and radiation therapy can themselves cause a rise in CEA due to death of tumor cells and release of CEA into the blood stream but that rise is typically temporary). "Carcinoembryonic" reflects the fact that CEA is made by some cancers ("carcino-") and by the developing fetus ("-embryonic").
* * *car·ci·no·em·bry·on·ic antigen .kärs-ən-ō-.em-brē-.än-ik- n a glycoprotein present in fetal gut tissues during the first two trimesters of pregnancy and in peripheral blood of patients with some forms of cancer (as of the digestive system or the breast) abbr. CEA
* * *(CEA) a glycoprotein secreted into the glycocalyx coating the luminal surface of gastrointestinal epithelia. Originally thought to be a specific antigen of the fetal digestive tract and adenocarcinoma of the colon, CEA is now known to occur normally in feces and pancreaticobiliary secretions and to appear in the plasma in a diverse group of neoplastic and non-neoplastic conditions, including cancers of the colon, pancreas, stomach, lung, and breast, alcoholic cirrhosis and pancreatitis, inflammatory bowel disease, rectal polyps, and cigarette smoking. The primary use of CEA is in monitoring response to treatment of colorectal cancer.
Medical dictionary. 2011.
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Carcinoembryonic antigen — (CEA) is a glycoprotein involved in cell adhesion. It is normally produced during fetal development, but the production of CEA stops before birth. Therefore, it is not usually present in the blood of healthy adults, although levels are raised in… … Wikipedia
carcinoembryonic antigen — [kär΄sə nō em brē än′ik] n. a glycoprotein found in serum, urine, etc. that is associated with various types of tumors: monitoring its levels is useful in treating cancer patients * * * … Universalium
carcinoembryonic antigen — [kär΄sə nō em brē än′ik] n. a glycoprotein found in serum, urine, etc. that is associated with various types of tumors: monitoring its levels is useful in treating cancer patients … English World dictionary
carcinoembryonic antigen — Antigen found in blood of patients suffering from cancer of colon and some other diseases, that is otherwise normally found in foetal gut tissue … Dictionary of molecular biology
carcinoembryonic antigen — n. CEA, antigen found in an increased amount in the blood of people who suffer from certain cancers (such as colon cancer) or other diseases and in the blood of heavy smokers … English contemporary dictionary
carcinoembryonic antigen — noun Date: 1967 a glycoprotein present in fetal digestive tract tissues and in peripheral blood of patients with some forms of cancer … New Collegiate Dictionary
carcinoembryonic antigen — CEA. A substance that is sometimes found in an increased amount in the blood of people who have certain cancers, other diseases, or who smoke. It is used as a tumor marker for colorectal cancer. Also called CEA … English dictionary of cancer terms
carcinoembryonic antigen — ¦kärsən(ˌ)ōˌ… noun Etymology: carcin + embryonic : a glycoprotein present in fetal gut tissues during the first two trimesters of pregnancy and in peripheral blood of patients with some forms of cancer (as of the digestive system or breast)… … Useful english dictionary
Carcinoembryonic antigen peptide-1 — is a nine amino acid peptide fragment of carcinoembryonic antigen (CEA), a protein that is overexpressed in several cancer cell types, including gastrointestinal, breast, and non small cell lung.Synonyms: * CAP 1 * Carcinoembryonic Antigen… … Wikipedia
carcinoembryonic antigen peptide-1 — CAP 1. A protein that can stimulate an immune response to certain tumors. Also called CAP 1 … English dictionary of cancer terms