luteinizing hormone–releasing hormone

1. a decapeptide hormone elaborated by the median eminence of the hypothalamus that binds to specific receptor sites on gonadotrophs of the adenohypophysis and stimulates the release of follicle-stimulating hormone and luteinizing hormone. High levels continuously maintained desensitize gonadotrophs and terminate gonadotropin release. Long-acting analogs are used to inhibit gonadal steroid secretion in individuals with prostate cancer and some other hormone-responsive cancers. Called also follicle-stimulating hormone–releasing h., gonadotropin-releasing h., gonadoliberin, and luliberin. 2. a preparation of the acetate and hydrochloride salts of this hormone obtained from the brains of certain food animals, used in the differential diagnosis of hypothalamic, pituitary, and gonadal dysfunction and sometimes in treatment of types of male or female infertility or hypogonadism.

Medical dictionary. 2011.

Look at other dictionaries:

  • follicle-stimulating hormone–releasing hormone — (FSH RH) luteinizing hormone–releasing h …   Medical dictionary

  • gonadotropin-releasing hormone — gonadotropin re·leas·ing hormone ri lēs iŋ n a decapeptide hormone produced by the hypothalamus that stimulates the adenohypophysis to release gonadotropins (as luteinizing hormone and follicle stimulating hormone) abbr. GnRH called also… …   Medical dictionary

  • luliberin — A decapeptide hormone from the hypothalamus that stimulates the anterior pituitary to release both follicle stimulating hormone and luteinizing hormone; gonadotropin releasing hormone. SYN: luteinizing hormone releasing hormone. [luteinizing… …   Medical dictionary

  • LH-RH — Abbreviation for luteinizing hormone releasing hormone. * * * luteinizing hormone releasing hormone * * * luteinizing hormone–releasing hormone …   Medical dictionary

  • combined anterior pituitary test — (for functioning of the anterior pituitary) four exogenous hypothalamic hormones are administered intravenously (corticotropin releasing hormone, growth hormone–releasing hormone, luteinizing hormone–releasing hormone, and thyrotropin… …   Medical dictionary

  • gonadoliberin — 1. A hypothalamic substance causing the release of gonadotropin. SYN: gonadotropin releasing factor, gonadotropin releasing hormone. 2. A decapeptide from pig hypothalami that induces release of both lutropin and follitropin in constant… …   Medical dictionary

  • FSH/LH-RH — follicle stimulating hormone and luteinizing hormone–releasing hormone; see gonadotropin releasing hormone, under hormone …   Medical dictionary

  • gonadorelin — n. a synthetic analogue of gonadotrophin releasing hormone (see LHRH analogue), administered by intravenous injection to stimulate the production of pituitary gonadotrophins. It is used in the treatment of amenorrhoea and certain types of… …   Medical dictionary

  • Gn-RH — gonadotropin releasing hormone; see luteinizing hormone–releasing hormone, under hormone …   Medical dictionary

  • bicalutamide — n. an anti androgen commonly used to treat prostate cancer because in men it blocks androgen receptors without reducing levels of testosterone in the blood, preserving libido and general energy levels. It is taken by mouth; side effects include… …   Medical dictionary

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