linkage disequilibrium

the occurrence in a population of two linked alleles at a frequency higher than the expected equilibrium frequency (which is the product of the frequencies of the two alleles), suggesting a common mutation due to a founder effect.

Medical dictionary. 2011.

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  • linkage disequilibrium — linkage disequilibrium. См. неравновесное сцепление. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Linkage disequilibrium — In population genetics, linkage disequilibrium is the non random association of alleles at two or more loci, not necessarily on the same chromosome. It is not the same as linkage, which describes the association of two or more loci on a… …   Wikipedia

  • linkage disequilibrium — noun A non random association of two or more alleles at two or more loci; normally caused by an interaction between genes, and often illustrated on a pairwise linkage disequilibrium diagram (HapMap) …   Wiktionary

  • linkage disequilibrium — See: gametic phase disequilibrium …   Glossary of Biotechnology

  • linkage disequilibrium — The occurrence of some genes together, more often than would be expected. Thus, in the HLA system of histocompatibility antigens, HLA A1 is commonly associated with B8 and DR3, and A2 with B7 and DR2, presumably because the combination confers… …   Dictionary of molecular biology

  • linkage disequilibrium —    The phenomenon of a specific allele of one locus being associated or linked to a specific allele or marker of another locus, on the same chromosome, with a greater frequency than expected by chance …   Forensic science glossary

  • pairwise linkage disequilibrium diagram — noun A triangular graphical representation of linkage disequilibrium in which different colours represent different magnitudes of linkage between pairs of loci …   Wiktionary

  • Disequilibrium — is a term used to describe the lack of or opposite of an equilibrium. in medicine: Disequilibrium (medicine) (DES) in cerebral palsy a syndrome described by Hagberg all[1] lack of equilibrioception in population genetics, linkage disequilibrium… …   Wikipedia

  • disequilibrium — A disturbance or absence of equilibrium. genetic d. a state in the genetic composition of a population which under selection may be expected to change toward an equ …   Medical dictionary

  • Transmission disequilibrium test — The transmission disequilibrium test (TDT) was proposed by [ db=pubmed dopt=Abstract list uids=8447318 Spielman, McGinnis Ewens (1993)] as a family based association test for the presence… …   Wikipedia

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