Any substance that inhibits or prevents the effects of thrombin in such a manner that blood does not coagulate. A deficiency of a. results in impaired inhibition of coagulation factors IIa, IXa, and Xa in plasma, causing recurrent thrombosis.
- a. III a plasma α2-globulin process that inhibits thrombin and has anticoagulant activities. Deficiency [MIM*107300] is commonly inherited as an autosomal dominant trait, caused by mutation in a. III gene (AT3) or chromosome 1q; this is one of the few known mendelizing disorders from which thrombotic disease occurs.
- normal a. an a. naturally occurring in blood and certain tissues under normal conditions in contrast to abnormal states or a. from other sources.

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an·ti·throm·bin -'thräm-bən n any of a group of substances in blood that inhibit blood clotting by inactivating thrombin compare ANTIPROTHROMBIN, HEPARIN

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an·ti·throm·bin (an″te-thromґbin) [anti- + thrombin] any naturally occurring or therapeutically administered substance that neutralizes the action of thrombin and thus limits or restricts blood coagulation. Six naturally occurring antithrombins have been designated by Roman numerals I to VI; antithrombins I and III are the most common and significant ones. Heparin is also considered an antithrombin.

Medical dictionary. 2011.

Look at other dictionaries:

  • Antithrombin — III Kalottenmodell nach PDB  …   Deutsch Wikipedia

  • Antithrombin —   [griechisch], bei der Blutgerinnung wirksamer natürlicher Hemmstoff; hemmt die Aktivierung von Thrombin und inaktiviert bereits gebildetes Thrombin …   Universal-Lexikon

  • Antithrombin — Serpin peptidase inhibitor, clade C (antithrombin), member 1 Antithrombin monomer drawn from PDB 2ANT …   Wikipedia

  • antithrombin — | ̷ ̷(ˌ) ̷ ̷| noun Etymology: International Scientific Vocabulary anti (I) + thrombin : a substance in blood that inactivates thrombin and prevents conversion of fibrinogen to fibrin compare heparin * * * antithrombin /an ti thromˈbin/ (medicine… …   Useful english dictionary

  • antithrombin — noun Date: circa 1911 any of a group of substances that inhibit blood clotting by inactivating thrombin …   New Collegiate Dictionary

  • antithrombin — noun a small molecule that inactivates several enzymes of the coagulation system …   Wiktionary

  • antithrombin I — fibrin; referring to the capacity of fibrin to adsorb large amounts of thrombin and thus neutralize (but not inactivate) it …   Medical dictionary

  • Antithrombin — Anti|thrombi̱n [↑anti... u. ↑Thrombin] s; s: Substanz im Blutplasma, die die Wirkung des ↑Thrombins aufhebt, d.Antithrombinh. die Blutgerinnung hemmt …   Das Wörterbuch medizinischer Fachausdrücke

  • Antithrombin — An|ti|throm|bin das; <zu ↑anti... u. ↑Thrombin> bei der Blutgerinnung wirksamer natürlicher Hemmstoff (Med.) …   Das große Fremdwörterbuch

  • antithrombin — adj. against thrombin (Medicine) …   English contemporary dictionary

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