cholesterol monooxygenase (side-chain-cleaving)
- ə-lesґtə-rol mon″o-okґsə-jən-ās sīd chān klēvґing) [EC 188.8.131.52] an enzyme of the oxidoreductase class that catalyzes the NADPH-dependent conversion of cholesterol to pregnenolone in a series of three reactions, successive hydroxylations of the 20 and 22 positions followed by cleavage of the side chain. The enzyme is a mitochondrial cytochrome P-450 acting as a terminal oxidase in an electron transport chain that also contains adrenodoxin and a flavoprotein. The reaction is the first step in the conversion of cholesterol to steroid hormones. Deficiency of the enzyme, an autosomal recessive trait, causes lipoid adrenal hyperplasia, a type of congenital adrenal hyperplasia (type I). Called also cholesterol desmolase and 20,22-desmolase.
Medical dictionary. 2011.
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Cholesterol monooxygenase (side-chain-cleaving) — In enzymology, a cholesterol monooxygenase (side chain cleaving) (EC number|184.108.40.206) is an enzyme that catalyzes the chemical reaction:cholesterol + reduced adrenal ferredoxin + O2 ightleftharpoons pregnenolone + 4 methylpentanal + oxidized… … Wikipedia
Cholesterol side-chain cleavage enzyme — Cytochrome P450, family 11, subfamily A, polypeptide 1 Identifiers Symbols CYP11A1; CYP11A; P450SCC External IDs … Wikipedia
cholesterol desmolase — cho·les·ter·ol des·mo·lase (kə lesґtər ol desґmol ās) cholesterol monooxygenase (side chain cleaving) … Medical dictionary
2022-desmolase — cholesterol monooxygenase (side chain cleaving) … Medical dictionary
P450SCC — cholesterol monooxygenase (side chain cleaving) … Medical dictionary
cytochrome P-450SCC — Cholesterol monooxygenase (side chain cleaving). [450 nm, the absorption maximum that the reduced cytochrome complexed with carbon monoxide exhibits] … Medical dictionary
List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH … Wikipedia