fourth-generation cephalosporin

a broad-spectrum cephalosporin having the greatest activity against gram-negative organisms of any of the cephalosporins. Cefepime is often so classified, although it is sometimes included with the third-generation cephalosporins.

Medical dictionary. 2011.

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  • Cephalosporin — See also: Discovery and development of cephalosporins Core structure of the cephalosporins …   Wikipedia

  • Discovery and development of cephalosporins — Cephalosporins are a broad class of bactericidal antibiotics that include the β lactam ring and share a structural similarity and mechanism of action with other β lactam antibiotics (e.g. penicillins, carbapenems and aztreonam).[1] The… …   Wikipedia

  • Cefquinome — Systematic (IUPAC) name 1 [[(6R,7R) 7 [[(2Z) (2 Amino 4 thiazolyl) (methoxyimino)acetyl]amino] 2 carboxy 8 oxo 5 thia 1 azabicyclo[4.2.0 oct 2 en 3 yl]methyl] 5,6,7,8 tetrahydroquinolinium inner salt …   Wikipedia

  • Beta-lactamase — Beta lactamases are enzymes (EC number|3.5.2.6) produced by some bacteria and are responsible for their resistance to beta lactam antibiotics like penicillins, cephalosporins, cephamycins, ertapenems and carbapenems. These antibiotics have a… …   Wikipedia

  • Cefepime — Systematic (IUPAC) name (6R,7R,Z) 7 (2 (2 aminothiazol 4 yl) 2 (methoxyimino)acetamido) 3 ((1 methylpyrrolidinium 1 yl)methyl) 8 oxo 5 thia 1 aza bicyclo[4.2.0]oct 2 ene 2 carboxylate …   Wikipedia

  • Blood-brain barrier — The blood brain barrier (BBB) is a metabolic or cellular structure in the central nervous system (CNS) that restricts the passage of various chemical substances and microscopic objects (e.g. bacteria) between the bloodstream and the neural tissue …   Wikipedia

  • cefepime — cef·e·pime (sefґə pēm) a semisynthetic fourth generation cephalosporin, having greater resistance to β lactamases than do the third generation cephalosporins …   Medical dictionary

  • Cefpirome — Drugbox IUPAC name = CAS number = ATC prefix = J01 ATC suffix = DE02 PubChem = 6917674 DrugBank = chemical formula = C=22|H=22|N=6|O=5|S=2 molecular weight = 514.58 g/mol bioavailability = protein bound = metabolism = elimination half life =… …   Wikipedia

  • Cefozopran — Drugbox IUPAC name = (6 R ,7 R ) 7 [ [(2 Z ) 2 (5 amino 1,2,4 thiadiazol 3 yl) 2 methoxyiminoacetyl] amino] 3 (imidazo [2,3 f ] pyridazin 4 ium 1 ylmethyl) 8 oxo 5 thia 1 azabicyclo [4.2.0] oct 2 ene 2 carboxylate width = 280 CAS number = 113359… …   Wikipedia

  • cefozopran — noun A fourth generation cephalosporin …   Wiktionary

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